- distinguished professor
- 免疫療法の（後出 immune system は免疫系、immune response は免疫反応、immunity は免疫力）
- がん（後出 anti-cancer drug は抗がん剤）
- 治療（後出 therapy も同意）
- unleash ～ on ...
- award ceremony
- co- ～
- trade name
Honjo Tasuku, distinguished professor at Kyoto University, has won the 2018 Nobel Prize in physiology and medicine for his discovery of a protein that helped lead to immunotherapeutic methods of cancer treatment, the Karolinska Institute in Sweden announced on Oct. 1.
The prize will be presented to Honjo, 76, and James Allison, 70, professor at the University of Texas.
The Karolinska Institute appreciated Honjo's discovery of PD-1 － a type of protein that regulates immune system function － which led to the development of cancer therapies unleashing the immune system on tumors by disabling the protein's function.
Honjo is the first Japanese national to win a Nobel Prize in two years and the 26th overall. The award ceremony is scheduled to be held in Stockholm on Dec. 10, and a total of 9 million Swedish kronur, or approximately 115 million yen, in prize money will be presented to Honjo and Allison.
At a news conference, Honjo expressed joy at winning the award. "It's an honor to win such a great prize. I'd like to express my gratitude to many people, including my co-researchers, students, those who supported our research, and my family," he said.
He said he is happy that the results of his research are being clinically applied and saving the lives of patients with serious cancers. "When I'm thanked by patients who recover, I truly feel the significance of our research," he commented.
In 1992, a research team led by Honjo found the PD-1 protein in T cells, a kind of lymphocyte that controls the immune system, and confirmed the protein regulates immune response. The team thought that if this function was disabled, it would enhance immunity and could be applied to fight cancer.
The development of anti-cancer drugs progressed based on this discovery. In September 2014, Ono Pharmaceutical Co. released a PD-1 inhibitor drug under the trade name "Opdivo."
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